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Notably, eight other fluoroquinolones (Levofloxacin, Gatifloxacin, Ofloxacin, Moxifloxacin, Marbofloxacin, Sparfloxacin, Perfloxacin and Norfloxacin), some of which are reported as radioprotectors 90 , were not hits in our drug screen (Supplementary Data 1)

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Esposito and colleagues hypothesized that their higher levels of pyruvate may not lead to larger benefit due to pyruvate's U-shaped dose-response curve (Esposito et al., 2007)

(49) have confirmed that in vitro treatment with UA can reduce the expression levels of fibrosis markers including vimentin, discoidin domain receptor tyrosine kinase 2, tensin and Alpha-smooth muscle actin in myocardial tissues, and inhibit the transition of cardiac fibroblasts to a fibrotic state through nuclear factor erythroid 2-related factor 2 signaling pathway