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There is supporting evidence reporting adverse effects from long-term rhIGF-1 treatment including neoplastic formation, cataract and renal hypertrophy, all of which seem to be the most severe effects observed and are usually rare [123, 282284]

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Beta-adrenergic receptors (3-AR): animal studies indicate increased RNA expression of 3-AR in fat cells following exposure to AOD 9604, which may enhance receptor sensitivity to lipolytic stimuli