glutathione peroxidase 1 pathway Frontiers Glutathione Peroxidases: An Emerging and

Key mitochondrial and antioxidant molecules such as Cytochrome c, UCH-L1, and thioredoxin domain-containing protein 12 were significantly downregulated

Release of glucuronic acid (reducing sugar) by acid or b-glucuronidase

To address these limitations, future research should prioritize: (1) developing more physiologically relevant preclinical models (e.g., humanized liver chimeras, diet-induced murine models with metabolic comorbidities) to better recapitulate human NAFLD pathophysiology

Independently of its function in the -secretase complex, PSEN1 itself is required for complete lysosomal acidification 108,117,118