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FIGURE 6 FIGURE 7 The Increased Menadione Resistance of the Mutants slr0236 , sll1545 , and slr0236-sll1545 Is Due, at Least in Part, to Their Higher Level of Catalase and/or Peroxidase Activity To search for players involved in the high menadione resistance of the mutants, we used standard protocols to measure the catalase and peroxidase activities of the Synechocystis bifunctional catalase/peroxidase enzyme ( 2 ) are detoxified by superoxide dismutase, which produces dioxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ), and catalase, which transforms H 2 O 2 to water and dioxygen

This mechanism establishes OLA as a promising anti-fibrotic therapeutic candidate ( Mitochondria-targeted antioxidants or CYP2E1 inhibition prevents this toxicity, highlighting CcO dysfunction as a key pathological mechanism ( Daphnia magna through its reactive metabolite NAPQI

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