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In contrast, hyperphosphorylation and aggregation of tau can disrupt iron export, resulting in neuronal iron accumulation and worsening neurofibrillary tangles (NFTs), creating a negative feedback loop (Wang and Mandelkow, 2016)

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These results may reflect the relapse of leukemia reported after the cessation of imatinib 6 , and suggest that curcumin has the good potential for tumor suppression