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The study was conducted in accordance with HIPAA and HITECH requirements, which expand upon the ethical principles detailed in the 1964 Declaration of Helsinki

By further comparing the gene expression profiles of the proline-treated group, the model group, and the control group from the above RNA-seq data, we obtained 4 DEGs, namely C-X-C Motif Chemokine Ligand 9 (Cxcl9), Z-DNA Binding Protein 1 (Zbp1), the 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (HMGCS2), and Azgp1 (Fig

Experimental studies suggest that DSIP influences the release of stress-related hormones such as adrenocorticotropic hormone and cortisol analogs in animal systems, indicating a role in feedback regulation of neuroendocrine stress pathways [4]

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