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Ferroptosis promotes immunogenicity by releasing DAMPs and lipid peroxides that mature dendritic cells and expand CD8 + T-cell populations, thereby boosting anti-tumor immunity (68)

Acetyl coenzyme A condenses to form 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA), which is then converted to MVA by HMG-CoA reductase

Consequently, the presence of cfDNA may act as the initiator for the activation of cGAS-STING signaling during RA progression