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This may influence the overall conclusions drawn from this review and caution should be exercised in interpreting the results

2 of 18 Journal of Biomedical Materials Research Part A, 2026 resulting in oxidative stress and tissue damage [6]

In addition, a consequence of a protracted hypertensive state establishment is the development of hypertrophy on the cardiac and renal levels, as was observed in SHRs that presented increased indices of left ventricular and renal weights compared with the normotensive WKY rat group