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129 Melatonin, an over-the-counter drug for treatment of insomnia, appears to exert anti-inflammatory, antiapoptotic, and antioxidant effects

"Nuclear transport, oxidative stress, and neurodegeneration"

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Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects