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if B12 levels were either at the high end of acceptable range, or higher than acceptable range, then the recommendation also included advice to review the frequency of the intervention and to consider changing from 3-monthly interventions to 6-monthly interventions

Metal ion chelation : Binds copper and zinc ions, preventing Fenton-type reactions that generate damaging hydroxyl radicals

This process can take weeks or months, which is why individuals may continue to feel emotionally fragile even after acute withdrawal symptoms subside