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W., McCulloch, W

Their findings revealed that aerobic exercise training provides neurovascular benefits for CKD patients as a 12-week cycling exercise showed robust efficacy in lowering the levels of resting muscle sympathetic nerve activity and aortic wave reflection determined via augmentation index, which, over time, increased in the control group

This highlights a core principle: B12 supplementation risks are not inherent to the vitamin alone but are a function of dose, individual health status, and context