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Bone marrow stem cells have also been used to successfully treat traumatic spine injuries, traumatic brain injuries and concussions by strengthening spinal tissue repair and preserving critical brain architecture as well as suppressing inflammatory signaling [42-43, 74-90, 97, 134-138, 162], and this effect may be augmented by temporary non-invasive blood-brain barrier opening using ultrasonic trans-cranial doppler while infusing the cells directly in the clinic