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However, IBN mice exhibited markedly impaired oligodendrocyte regeneration and remyelination compared to control mice in the presence of interferon (IFN-) ( + mice developed much more severe EAE because oligodendrocytes from these mice were more vulnerable to inflammation than those from control mice ( Oligo ) showed a decrease in the loss of mature oligodendrocytes, which in turn prevented demyelination upon EAE challenge ( Oligo mice was more dependent on controlling oligodendrocytes themselves, while the change in inflammation was not significant

J Med Chem 58:40664072

Mechanistically, lycopene functions through both physical and chemical quenching of reactive species (122124)

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