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10.1016/j.jconrel.2019.06.018 J

Constipation, while less common than diarrhea, may also occur and can be particularly problematic in patients with pre-existing constipation issues

Abstract Sleep deprivation disrupts the lives of millions of people every day and has a profound impact on the molecular biology of the brain

However, although it has already been shown that greater activation of hyperinflammation-related pathways is associated with disease severity ( Table 1 and Table S1 )