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These factors collectively highlight the multifactorial nature of gallstone disease [37]

Cachexia: a problem of energetic inefficiency

12 Although no single test can establish a tumor as an MS, Torres-Mora and colleagues 19 explained that MS can be differentiated from melanoma by tumor location and morphological appearance because MSs have a more spindled cell shape, greater nuclear pleiomorphism, and lower mitotic rate than melanomas