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Med Chem 13:214225 Jalili-Baleh L, Forootanfar H, Kkkln TT, Nadri H, Abdolahi Z, Ameri A, Jafari M, Ayazgok B, Baeeri M, Rahimifard M, Abbas Bukhari SN, Abdollahi M, Ganjali MR, Emami S, Khoobi M, Foroumadi A (2018) Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimers disease based on coumarin and lipoic acid scaffolds

doi: 10.1016/j.foodchem.2016.05.074 139 PujiastutiD

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Disulfiram: DSF is a dithiocarbamate compound that treats alcohol dependence by targeting aldehyde dehydrogenase (ALDH), while acid condition reduces DSF to diethyldithiocarbamate (DTC) and invests the capacity to combine Cu(II) (Viola-Rhenals et al., 2018)