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Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting

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Some possible mechanisms include increased glutamate generation induced by pro-inflammatory substances (such as TNF-) (Santello and Volterra, 2012), leading to brain excitotoxicity and increased intracellular Ca 2+ concentration promoting glutamate, ATP, and GABA release (Parpura et al., 1994