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Fluctuations in copper homeostasis during HF may disrupt mitochondrial function and exacerbate oxidative stress (66)

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This study is of particular interest because the researchers also paired gene studies with laboratory studies, confirming that changes in gene expression are associated with improved collagen reorganization and fibroblasts function [ 28 ] Further studies confirmed the ability of GHK-Cu to reverse gene expression in COPD back to health [ 29 ]

Additionally, dimerization can stabilize proteins, helping them maintain their functional conformation and resist denaturation under physiological conditions as well as regulate intracellular signaling molecules 9,10