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Emergency Physician at Kelowna hospital, British Columbia

Sasaki T, Ghring W, Mann K et al (1997) Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens

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In addition, vascular endothelial cells are damaged, and the normal proportion of endothelin-1 and NO secreted by them to maintain the vasomotor function is broken