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The magnitude of difference was particularly notable for weight loss, suggesting that GIP receptor activation contributes meaningfully to metabolic improvements beyond GLP-1 effects alone

Acknowledgements We are grateful for financial support provided by the National Key Research and Development Program of China (2017YFD0200500), NSFC (21971065, 21722202, 21672069), the S&TCSM of Shanghai (18JC1415600), Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, National Program for Support of Top-notch Young Professionals, and Innovative Research Team of High-Level Local Universities in Shanghai