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B12 deficiency is common, especially in people who follow a vegetarian or vegan diet

A 2025 Stanford Medicine study identifying a naturally occurring peptide that suppressed appetite and reduced body weight without the nausea and muscle loss associated with semaglutide confirmed what many clinicians had already observed: the GLP-1 mechanism is powerful, but it carries side effects tied directly to how it works

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Metabolic relevance: Provides insights into adipocyte function, fat storage, and energy balance