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10.3390/ijerph10093886 159 ValkoM.LeibfritzD.MoncolJ.CroninM

2017;313(4):H76881

Several research findings suggest that oxidative damage resulting from disproportion between reactive oxygen metabolites (ROMs) production and antioxidant activity generates deleterious effects on signal transduction, mitochondrial complex (I-IV) activities, structural plasticity, oxidation of proteins, and lipid peroxidation in membranes and genes leading to neuronal death (Takuma et al., 2004)