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In one study, an acid-resistant HP55/PLGA nanoparticle oral vaccine system elicited high levels of specific antibodies and memory T cell responses in mice, significantly reducing bacterial load and achieving 43% complete protection (Tan et al., 2017), confirming the significant potential of encapsulating vaccine antigens to enhance oral vaccine effectiveness

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Bradley A W, Guilherme Piovezani R, Sunanda K