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Vitamin K cannot be produced physiologically by human cells but can be synthesized by the gut microbiota (vitamin K2 or menaquinone) ( Vitamin K deficiency is rare in adults, primarily due to malabsorption, total parenteral nutrition, or antibiotic use (which reduces gut bacteria production of vitamin K), a common issue in oncology wards

Among the three RAS genes (H-, K- and N-RAS), the highest mutation frequency was observed for the K-RAS gene in lung cancer (6.5% frequency for squamous cell carcinoma and 26% for adenocarcinoma in Western populations) (66)