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For example, K63-linked chains affect protein interactions and chromatin recruitment (Wang et al., 2017), while K11 chains may fine-tune timing and subcellular localization of clock protein degradation ( 4 E3 ligases and deubiquitinating enzymes in circadian regulation 4.1 E3 ligases and their role in circadian regulation 4.1.1 E3 ligases E3 ubiquitin ligases, though structurally built on a limited set of catalytic domains, achieve functional diversity through specialized substrate recognition and regulatory elements

Halvey PJ, Hansen J, Johnson J M, Go YM, Samali A, Jones DP (2007) Selective Oxidative Stress in Cell Nuclei by Nuclear-Targeted D-Amino Acid Oxidase

Pathological staging was performed in accordance with the Scheuer and Nakanuma classifications (SC and NC)

M.et al (1991)