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In animal models, it has been reported that the activation of apoptosis in type II AEC promotes a fibrotic phenotype, for example, apoptotic cells may release cytokines and growth factors that recruit and activate fibroblasts, prompting them to secrete ECM, whereas inhibiting apoptosis helps to alleviate pulmonary fibrosis (102104)

Office of Dietary Supplements Riboflavin

Salimi Shahraki H, Qurtulen, Ahmad A

In addition, they showed long-term HPA axis alterations in activity, as evidenced by increased mean glucocorticoid concentrations resulting from an increase in glucocorticoid pulse frequency and amplitude