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This is an extremely promising result because the ALC seems to be getting at the underlying cause of hypothalamic amenorrhea insufficient GnRH pulses from the hypothalamus

Finding that body weight and body mass index (BMI) were comparable at baseline and remained unchanged in different groups and strata during the study reasonably excludes the possibility that study results were confounded by systematic changes in diet and physical activity introduced during the trial

S., Luscombe-Marsh, N

In retinoblastoma cells, RAR was also involved in RA-induced activation of signaling cascades mediated by tyrosine kinases known as phosphoinositide 3-kinase (PI3K) and leading to cell differentiation (11, 12)