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Poor communication between the brain and gut could cause changes in brain 5-HT and tryptophan concentrations, leading to anorexia and OD ( In addition to various symptoms caused by SARS-CoV-2 infection, the gastrointestinal symptoms caused by COVID-19 are also closely associated with the imbalance of gut microbiota, which could also influence other systems through various axes (Scheithauer et al., 2024