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Description

Mauldin, and JoEllen M

Methods: Fibroblasts from Alzheimers patients with APOE 3/4 + G206D-PSEN1 mutation and homozygous APOE 4 were used to study the effects of APOE polymorphism and PSEN1 mutation on the autophagy pathway, mitochondrial network fragmentation, superoxide anion levels, lysosome clustering, and p62/SQSTM1 levels