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Clinical trial design must account for this heterogeneity, possibly incorporating patient stratification based on imaging, genetic risk factors (e.g., APOE or TREM2 variants), or peripheral cytokine profiles

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Glutathione (GSH) is the fully assembled tripeptide consisting of glutamate, cysteine, and glycine, whereas precursor compounds participate in upstream glutathione biosynthetic pathways

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Polysaccharides are the third major group of compounds in C

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In glycolysis, PYR is the final cytosolic product of glucose metabolism and serves as a key intermediate, undergoing oxidative decarboxylation by the PDH complex to generate acetyl-CoA

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