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Evidence from genetics GWAS have also implicated specific myelin/OLG-related genes in neurodegeneration, including the bridging integrator 1 ( BIN1 ) gene, which is the second strongest genetic risk factor for late onset AD [45, 57, 58] and known to be largely expressed by mature OLGs and localised to white matter tracts [86]

Ferroptosis is directly influenced by the transport of cystine, the activity of glutathione peroxidase 4 (GPX4), the reduction of Fe, and the Fenton reaction