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Peter Attia, MDa longevity and wellness expert and host of the The Drive podcast discusses this in detail in his blog post, Lean mass loss on GLP-1 receptor agonists: a downside of the miracle drugs. He discusses how Ozempic causes both muscle and fat loss and does not improve body composition as much as natural weight loss methods

It may manifest itself as itching, eczema, urticaria, reddening of the skin, or even localized skin lesions which may progress to destruction of the skin cells (necrosis), swelling (angioedema), or allergic shock (intense generalized malaise)

Of slightly greater concern, but to only a very few people, is the presence of the cobalt