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The peptide does not appear to significantly affect glucose metabolism or insulin sensitivity in the way that full-length growth hormone does - growth hormone causes insulin resistance through various mechanisms, whereas AOD9604 has been reported to be neutral or possibly even beneficial for insulin sensitivity

On the other hand, lipid-soluble antioxidants as vitamin E cross the BBB slowly and may require prolonged exposure to achieve meaningful brain concentrations, where none of the vitamin-based AMS trials assessed these agents reach the relevant target tissues, this evident limitation strongly constrains interpretation of clinical outcomes and underscores the PK-PD disconnect between theoretical neuroprotective effect and observed efficacy (Table 3)

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