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7 Other potential mechanisms that have been described include increasing total fecal nitrogen excretion due to increased stool mass 8 and reducing the formation of toxic fatty acids and ammonia in the colon

In the SZ PFC, a lower number of cells expressing OLIG2 (a marker for all cells of the OL lineage) is observed, with no changes in the number of OPCs, suggesting that indeed PFC OPC maturation impairment in SZ is a likely cause of the lack of myelination in this brain area

Coupling of the transcriptional regulation of glutathione biosynthesis to the availability of glutathione and methionine via the Met4 and Yap1 transcription factors

Conclusion: There is a high risk of rebound when TDF is stopped after delivery in pregnant women with immune tolerance