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Immunoblot of indicated proteins in HeLa cells treated with Erastin (5 M) or indicated doses of RSL-3, an inhibitor of glutathione peroxidase 4 (GPX4) for 24 hours

Social isolation of adult mice impaired myelination in the prefrontal cortex (PFC) (Liu et al., 2012), while clemastine rescued the behavioral changes (Liu et al., 2016)

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Moreover, xCT is also expressed in the normal colon, but it was demonstrated that its overexpression in colorectal tumors is associated with the activation of MELK oncogene and Pi3K and RAS pathways, being xCT pharmacological blockade a way of affecting cancer cells tumorigenesis (111)