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Description

In vitro experiments have demonstrated that bioactive LMW-HA fragments may drive an inflammatory matrix environment via eosinophils and directly impair gamete quality by compromising granulosa cell function, thereby contributing to reproductive aging 98

10.3389/fphar.2017.00548 13

The findings stimulate further studies in large biobank samples to clarify whether such signatures could prove valuable for detecting pathology or follow-up of treatment effect in clinical trials