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But this research shows that, at normal biological levels, small increases in prostaglandin E2 can promote regeneration. A closer investigation of the chondrocytes in the joints of old mice and young mice showed that old chondrocytes expressed more detrimental genes involved in inflammation and the conversion of hyaline cartilage to unwanted bone, and fewer genes involved in cartilage development

Caffeine affected more inflammatory pathways than EGCG, suggesting that caffeine is more involved in inflammation-related pathways

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doi:10.7860/JCDR/2017/23626.9732 Mohd Ghozali N, Giribabu N, Salleh N