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Proline synthesis and proline cycling participate in redox signaling, and targeting proline metabolism may be an effective adjunct cancer therapy (Phang, 2019)

Intestinal regeneration: regulation by the microenvironment

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Meanwhile, gut microbiota dysbiosis also had strong influence on OA development through the gut-joint axis: intestinal barrier disruption, increased endotoxemia throughout the body, and decreased SCFA all drove joint degeneration