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Clinical trials in the general obesity population demonstrated average weight loss of approximately 15% of body weight over 68 weeks, with somewhat lower efficacy in patients with type 2 diabetes

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It is advisable to avoid valproic acid, as it can impair liver mitochondrial function and cause hepatotoxic, while carbamazepine and phenytoin can decrease vitamin B12 and folic acid levels, therefore, these drugs should be avoided whenever possible

Ipamorelin is the first selective GH secretagogue