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CKs and their receptors regulate tumor cells proliferation and metastasis through various signaling pathways (148)

One of the reasons for this accumulation is an increased mitochondrial membrane potential that occurs upon cysteine deprivation

In contrast, Pacer, which mediates autophagosome binding by STX17, acts as an antagonist of rubicon to activate the VPS34-UVRAG subcomplex, target the autophagosome, and recruit VPS34 and HOPS to promote autophagosome maturation (Matsunaga et al., 2009