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TRP residues in proteins, especially the pyrrole ring of the indole nucleus, are susceptible to oxidation by ROS and can contribute to altered structure, protein function, and the pathogenesis of various disorders [45]

Aging is associated with increased activity of the TRP-KYN pathway due to upregulated cortisol production, an activator of TDO, and the presence of proinflammatory cytokines, which induce IDO [80]

277 Social jetlag, a term that refers to the difference between sleep timing that is adjusted for socially necessary schedules (eg, during the work or school week) and natural sleep timing (eg, on the weekend when there are no social pressures), can be a cause of sleep loss and has been linked to negative health outcomes