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Research in recent years has provided valuable insights into how these macrophage phenotypes influence the fibrotic pathway, highlighting the complexity of their roles

Whereas MAMs seem to be more specific to Met than to Leu, the large subunit of IPMI the IPMI-LSU1 functions not only in aliphatic GSL biosynthesis but is still active in Leu biosynthesis (Knill et al., 2009

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The arachidonate lipoxygenase (ALOX) family is a class of non-heme iron-containing enzymes that can catalyze polyunsaturated fatty acids (PUFAs) oxygenation to generate various hydroperoxy PUFA derivatives, such as the initial lipid hydroperoxides and subsequent reactive toxic aldehydes, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE)