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Excessive mitochondrial ROS, especially superoxides (O2 - ), hydrogen peroxides (H 2 O 2 ) and hydroxides ( OH), characterize obesity adipocyte dysfunction

Posma, J

While CD19-directed CAR T-cell therapies revolutionized treatment of hematological malignancies (123), translating this success to solid tumors, and especially into the CNS, has posed more of a challenge due to antigen heterogeneity, the immunosuppressive TME, and the restrictive BBB