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To address this gap, researchers conducted a randomized, double-blind, placebo-controlled trial with a three-month follow-up to examine the effects of ALA supplementation on mitochondrial and vascular markers as well as migraine symptoms. The study included 92 women between the ages of 20 and 50 years who were diagnosed with episodic migraine and had experienced symptoms for at least six months. Participants were randomly assigned to receive either 300 mg of alpha-lipoic acid (ALA) twice daily for three months or an identical placebo

Ishikawa H, Takaki A, Tsuzaki R, et al