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Nat Rev Clin Oncol (2012) 9(12):68899

Cell differentiation effects of 2'-fluoro-1-beta-D-arabinofuranosyl pyrimidines in HL-60 cells

It has been reported that epithelial-specific deletion of the focal adhesion kinase (FAK), which is necessary for cell migration, leads to epithelial cell apoptosis and enhanced bleomycin injury, while enhancement of the Notch signaling pathway leads to functional impairment of Tp63-expressing stem cells in the bronchiolar epithelium

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