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These challenges include the short half-life and instability of the protein in vivo [106], the requirement of administering high volumes of endostatin to exert their anti-angiogenic effects, which in itself is associated with significant practical and cost implications [107], as well as technological challenges related to manufacturing a correctly folded and soluble protein to ensure adequate bioactivity within the tumour cells [108]

Least significant difference (LSD) post hoc tests were used

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Semiology and examination Examination of patients with TN should seek to identify trigger points whose stimulation generates pain with similar characteristics to that described by the patient