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The melatonin administration before or alongside CP treatment preserved the ovarian reserve by maintaining the number of primordial, primary, and growing follicles, reducing follicular atresia, and activating the Hippo signal pathway (Xu et al

Numerous drugs have been developed to target the VEGF pathway with receptor tyrosine kinase inhibitors, with soluble decoy receptors, or with antibodies targeting the VEGF ligand or receptor