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With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels

Biol Psychiatry (2006) 60:20717.10.1016/j.biopsych.2006.05.005 248 OquendoMAHastingsRSHuangYYSimpsonNOgdenRTHuXZet alBrain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography