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Insulin-like growth factor I increase glomerular filtration rate and renal plasma flow in man

2015;16(1):108116 [PubMed: 25524795] 87

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This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH