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Description

Hepatology 11 , 2430 (2005)

10.1136/bmj.285.6334.20 286

From hypoxia and hypoxia-inducible factors (HIF) to oxidative stress: A new understanding of the toxic mechanism of mycotoxins

At epithelial surfaces, secreted and membrane-anchored oxidases of the DUOX family deliver H 2 O 2 into the mucosal milieu, where it supports barrier integrity, fuels lactoperoxidase-mediated antimicrobial chemistry and acts as a paracrine signal that coordinates wound closure and innate immune recruitment without triggering wholesale oxidative damage when spatially confined (Sarr et al